High Shear Mixer Granulator

The High Shear Mixer Granulator (HSMG), also known as a Rapid Mixer Granulator (RMG), is designed for efficient powder mixing and wet granulation in pharmaceutical manufacturing. It combines intensive mixing and granule formation within a single processing bowl, helping achieve the desired granule characteristics for downstream operations.

Intence Engineering offers High Shear Mixer Granulators with specially designed impellers, optimized bowl geometry, and controlled mixing operations. The equipment supports efficient processing, flexible batch requirements, and convenient cleaning and maintenance, making it suitable for pharmaceutical and allied manufacturing applications.

Applications of High Shear Mixer Granulator

1. Pharmaceutical Wet Granulation: Mixing active pharmaceutical ingredients (APIs) and excipients with binder solutions to produce granules for tablet manufacturing.
2. Powder Mixing and Homogenization: Blending dry powder ingredients to promote uniform material distribution before wet granulation.
3. Granule Formation: Producing granules with suitable flowability and compressibility for subsequent drying, milling, and tablet compression.
4. Research and Production: Supporting granulation process development, laboratory trials, pilot-scale operations, and commercial pharmaceutical manufacturing.

Key Features

• Specially Designed Impeller: Supports efficient mixing and granule formation.
• Optimized Bowl Design: Bowl geometry designed to minimize dead spaces during processing.
• Efficient Granulation: Short mixing and granulation cycles for achieving the desired granule profile.
• Flexible Working Volume: Working capacity ranging approximately from 30% to 80% of bowl volume.
• Process Monitoring: Ampere-based endpoint detection for monitoring the granulation process.
• Impeller Air Purging: Air-purging arrangement at the main impeller.
• Scale-Up and Scale-Down: Equipment options suitable for different batch capacities and process requirements.

Optional and Additional Features

• Vacuum or gravity charging systems
• Bottom impeller lifting for easier cleaning
• Electromechanical impeller removal for maintenance and product changeover
• Hydraulically operated lid lifting
• Binder spraying systems
• Jacketed processing bowl options
• Torque sensor-based endpoint determination
• SCADA solutions with 21 CFR Part 11-oriented functionality
• ATEX / flameproof configuration options
• 2 Bar / 12 Bar pressure-resistant design options
• Through-the-wall and containment configurations
• Wash-in-Place (WIP) systems

Available Capacity

Gross Bowl Capacity: 1 L to 1,800 L

Intence Engineering offers High Shear Mixer Granulators across a wide range of capacities, from laboratory-scale equipment to production-scale systems, depending on customer and process requirements.

Intence Engineering – Granulation Solutions

Intence Engineering provides High Shear Mixer Granulators designed to meet diverse pharmaceutical processing requirements. With configurable equipment designs, process control options, and integrated granulation solutions, the company supports efficient powder processing and consistent granulation operations across different production scales.

Intence Engineering Pvt. Ltd. is a manufacturer of High Shear Mixer Granulators, providing engineered solutions for powder mixing, wet granulation, and pharmaceutical solid dosage manufacturing.